Abstract The extraction, evaluation and refining of fish oil from mackerel scomber scrombrus ; has been conducted in this work. The total percentage oil yield using solvent extraction and total moisture content was 28.24% and 56.50 %respectively, which were found to increase linearly with time. The analytical properties of the crude and the refined oil were evaluated. It was observed that the crude oil consist from: acid value 2.5 mg KOH, peroxide value 2.19 mEq kg, saponification value 201.6 mgKOH g, iodine value 108.09 I2 100g, specific gravity 0.911, refractive index 1.485 and reddish brown colour. The refined oil was also evaluated as follows: acid value 2.27 mg KOH, peroxide 1.00 meq kg, saponification value 147.84 mgKOH g, iodine value 106.93 I2 100g and golden brown colour. These values fall within the acceptable standard values. The refining of the oil brought about a notable improvement in the analytical properties of the oil. Thus, leads to a high quality fish oil in terms of the taste, colour, odours, shelf life and market value. Based on the improved characteristics of the oil, it could be suitable for applications in pharmaceutical and food industries. Keywords Mackerel, Scomber Scrumbus, Fish oil.
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COMT inhibitors Entacapone A selective and reversible peripheral COMT inhibitor with a short plasma half-life 1.5 hours ; and a short-lasting enzymatic blockade. The drug increases the plasma elimination half-life of L-dopa without increasing peak absorption Cmax ; , and reduces the plasma levels of 3-oxy-methyldopa, a metabolite that potentially competes with L-dopa for the carrier at the level of the blood-brain barrier. Some open-label studies have shown that the increase in the plasma half-life of L-dopa is associated with an increase in the duration of action of L-dopa itself, as shown by a reduction in wearing-off phenomena [32, 33]. Large-scale controlled studies [3436] have shown an increase in the onperiod of one hour [34], one hour and 24 minutes [35], and one hour and 42 minutes [36] in patients with fluctuations, with a simultaneous possibility of reducing the L-dopa dose by 50100 mg day 927% of the daily dose.
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HCV NS3 HELICASE INHIBITORS A few small-molecule inhibitors of the NS3 helicase with activity in vitro have been reported, but their inhibitory mechanisms, specificity and potential efficacy in the clinical setting remain unclear. HCV RDRP INHIBITORS One category of inhibitors of viral polymerases is nucleoside substrate ; analogues cyclic or acyclic ; . Inhibitors of the HCV RdRp have been identified through the use of high throughput screening. Several of these compounds have encouraging preclinical profiles. Preliminary in vitro results suggest that resistance to RdRp inhibitors may occur in the clinical setting. A few orally bio-available inhibitors of the HCV RdRP are under study in early clinical trials, such as JTK-003 and JTK-109, and NM283.The efficacy of NM283 against HCV genotype 1 was established in a one week study in chronically infected chimpanzees. Median drops in HCV viral load of -0.83 and -1.05 log10 were observed. NM283 has recently entered early phase clinical trials. ANTIFIBROTIC APPROACHES The liver offers a unique advantage as a target for orally administrated antifibrotic agents, since those with efficient hepatic first-pass extraction will have inherent liver targeting by minimizing systemic distribution and non-liver adverse effects. New antifibrotic therapies may be derived from at least three sources: i ; existing drugs with established safety profiles which may gain an additional indication for use in hepatic fibrosis for example: IFN alfa, angiotensin conversion enzyme inhibitors, TNF alfa antagonists, antioxidants, IFN gamma, etc ii ; drugs under development for other diseases that may have additional value in hepatic fibrosis; and iii ; agents specifically developed for use in liver and
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